Čítačka správ

Nové zistenia doporučujú dávať deťom arašidy a vajíčka už od štyroch mesiacov veku. Dôkazov stále pribúda.

Analýzy DNA troch genetických tímov posilňujú argumenty o jedinej veľkej migrácii.

Evolúcia si znova našla cestu. Niektorí majú o dôvod viac, prečo k pavúkom prechovávať odpor.

Najnovší únik informácií o pol miliarde účtov Yahoo je upozornením, že jednoduché heslo patrí do minulosti.

Jednoduchý nástroj zobrazí rozsah úniku dát a odporúči zmeniť heslo.

Americká spoločnosť doručila zásielky do ťažko dostupných oblastí.

Odporný sladkastý zápach sa šíri vo vzduchu vo chvíli, keď dvanásťročnú koaliu samičku Robyn prinášajú na malú vyšetrovňu prvej austrálskej nemocnice.

Milióny užívateľov rôznych webových služieb sa v roku 2016 dozvedeli o svojom ohrození.

Sledovanie tragédií vedie k lepšej odolnosti na bolesť aj k silnejším vzťahom.

Moskytom by z tejto televízie malo neznesiteľne "pišťať v ušiach". Spoločnosť LG Electronics predstavila televíziu so zariadením, ktoré vydáva zvukové vlny.

Priemerná sledovanosť videí nebrala do úvahy tých, čo videá zastavili do troch sekúnd.

Zariadenie skráti trojtýždňové čakanie na 15-minútovú previerku.

Spoločnosť ESET objavila podvodné správanie, ktoré sa zameriava špeciálne na administrátorov facebookových skupín.

Satirický časopis už 26. krát ocenil výskumy, ktoré majú najskôr pobaviť a potom sa máme nad nimi zamyslieť.

Na energetických štítkoch by bola pravda iba vtedy, ak by ste sa uspokojili so zlým obrazom.

Some good news! We recently published an article in Nature titled "Accurate de novo design of hyperstable constrained peptides". We would like to thank all Rosetta@Home participants for their help with this work. In the paper, we present computational methods for designing small stapled peptides with exceptional stabilities. These methods and designed peptides provide a platform for rational design of new peptide-based therapeutics. Constrained (stapled) peptides combine the stability of conventional small-molecule drugs with the selectivity and potency of antibody therapeutics. The ability to precisely design these peptides in custom shapes and sizes opens up possibilities for "on-demand" design of peptide-based therapeutics. Other developments described in the paper: We can now accurately design 18-47 amino acid peptides that incorporate multiple cross-links. We can now design peptides that incorporate unnatural amino acids. Specifically, we designed peptides with a mix of natural L-amino amino acids and D-amino acids (mirror images of L-amino acids). D-amino acids tend to provide better protease resistance and lower immunogenicity; both of which are desired properties in a therapeutic peptide. Unnatural amino acids also let us sample much more diverse shapes and functions. We can now design peptides that are cyclized via a peptide bond between their N- and C-terminus. Cyclic peptides provide increased resistance against exopeptidases as they have no free ends, and thus are ideal candidates for engineering peptide therapeutics. We are now working to use these computational methods for designing peptides that target therapeutically relevant targets, such as, enzymes that impart antibiotic resistance in pathogenic bacteria. Structure prediction runs on Rosetta@Home for these designed peptide models played a key role in selection of good designs that were experimentally synthesized and characterized. Thank you all for your help in making this work possible! -- Gaurav B. For more information: IPD News. Nature paper "Accurate de novo design of hyperstable constrained peptides". Nature review "The coming of age of de novo protein design".

Predpovedať, či bude na Slovensku v budúcnosti dosť vody sa nedá ľahko, vysvetľuje hydrologička PAVLA PEKÁROVÁ z SAV.

We have added the option to access the C@H website more securely via "https", if you'd like to do so, you can update your bookmarks to use https://www.cosmologyathome.org. For now this remains purely optional (for example, if you don't know what https is, you can ignore this). At some point in the future, we will likely move to requiring this, but we'll give warning and post more details then.

Also, I've fixed a number of minor cosmic things about the site, most notably 1) the BBCode buttons when posting to the forums now work 2) a number of pages which were rendered too wide should now correctly fit the screen. If, as you're using the site, you find any other glitches, please don't hesitate to take a screenshot and post on the forums so we can fix things! Thanks all! (Edit: ha, oops meant to say *cosmetic* things above, although I'll leave in the somewhat appropriate typo)

Firma priznala útok na viac ako 500 miliónov účtov.

Zvieratá sa podľa počasia samé rozhodli, či potrebujú deku.